Review of Ammonium Dinitramide Toxicity Studies

Abstract

Ammonium dinitramide (ADN) is a class 1.1 explosive oxidizer being considered for use in solid rocket propellant mixtures. Studies performed evaluating the toxicity of ADN have included an acute and subacute toxicity screen, a 90-day reproductive screen and three follow-on reproductive studies, electron paramagnetic resonance (EPR) spectroscopy studies, mutagenicity assays and a study evaluating the effects of ADN on hepatocytes in vitro. The LD50 in rats is 823 mg/kg, indicating ADN is moderately toxic. The results also indicated that ADN is a female reproductive toxicant in rats, causing implantation failure in early gestation; follow-on studies implied that ADN is embryotoxic. EPR studies indicated that ADN can decompose to form reactive nitrogen metabolites which can be harmful in biological systems. The hepatocyte studies suggested that ADN has the potential for directly affecting cellular DNA in vitro; these results are supported by traditional genotoxicity assays which reported that ADN is mutagenic.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2011
Accession Number
ADA545795

Entities

People

  • David R. Mattie
  • Teresa R Sterner

Organizations

  • Henry M. Jackson Foundation for the Advancement of Military Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Air Force Research Laboratories
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Electron Nuclear Double Resonance
  • Electron Paramagnetic Resonance
  • Energetic Materials
  • Genotoxicity
  • Liquid Chromatography
  • Paramagnetic Resonance
  • Propellants
  • Resonance
  • Rocket Propellants
  • Solid Rocket Oxidizers
  • Solid Rocket Propellants
  • Toxicity

Readers

  • Aquatic Ecology
  • Toxicology/Environmental Toxicology

Technology Areas

  • Microelectronics