The Carcinogenic Potential of JP-8 and Tungsten in C57BL/6 Mice
Abstract
Little of the etiology of childhood leukemia is known; evidence indicates that childhood leukemia is a genetic disease originating in utero. Because of the probable multi-factor etiology of leukemia, multi-exposure investigations will contribute more useful information than conducting only single exposure studies. The combination of two environmental exposures, jet propellant-8 (JP-8) and tungsten (W), is unique to military personnel and their families. In the current study, we have used an animal model to investigate the effects of in utero exposure to environmental and occupational toxicants (tungsten and JP-8) in combination with infection by MHV-68 virus (murine Epstein-Barr virus) on the development of leukemia-like alterations. Unlike previous results using respiratory syncytial virus, our preliminary results show that exposures using MHV-68 have not resulted in any alterations in blood cell profiles or in spleen sizes. This indicates that the overall response therefore, may be specific for particular viral interactions and is not just a general effect of the JP-8 or tungsten on inflammatory responses. Research is continuing to verify the current preliminary results.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 31, 2011
- Accession Number
- ADA546076
Entities
People
- Robert C. Lantz
Organizations
- University of Arizona