Genomic Instability and Breast Cancer
Abstract
We are continuing our investigation of mechanisms underlying the maintenance of genomic stability and breast cancer development. Our analyses on BRCA1 and DNA damage response have resulted in the identification of several new components involved in DNA damage signaling pathways and revealed how these pathways act together to ensure genomic stability in response to DNA damage. In addition, we have performed a series of studies focusing on replication checkpoint control, which help us to understand how stalled replication forks are protected in vivo for the maintenance of genomic integrity. We have already published some of these exciting discoveries. We hope that the ongoing studies will continue to provide new insights into breast cancer etiology and identify new targets for cancer therapy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2011
- Accession Number
- ADA546325
Entities
People
- Junjie Chen
Organizations
- The University of Texas MD Anderson Cancer Center