Antibody-Functionalized Carbon Nanotube Transistors as Biosensors for the Detection of Prostate Cancer
Abstract
During year 1 of this award we successfully met nearly all benchmarks proposed in our joint statement of work. This was accomplished through active interaction between the two groups. Face-to-face meetings, video conferences, and numerous email communications and trips between sites to deliver reagents allowed for useful discussions and insured rapid research progress. The Johnson group successfully fabricated and tested swCN transistors with covalently bound scFv antibodies specific for to one of our proof-of-concept biomarkers that had been developed by the Robinson group. We are now in position to begin testing sensitivity of our swCN sensors and developing optimized strategies for functionalizing the sensors with scFv antibodies. The ultimate goal of this research is the development of a prototype biosensor that will be used to retrospectively test patient samples during year 3 of this award. The research accomplishments achieved in year 1 have positioned us well for meeting this goal. Assuming our hypothesis of increased sensitivity over current technology is correct, by the end of this funding period we aim to have generated sufficient data to support the development of this sensor platform.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2010
- Accession Number
- ADA546345
Entities
People
- A. T. Johnson
- Matthew T. Robinson
Organizations
- University of Pennsylvania