Glycomic Analysis of Prostate Cancer

Abstract

In this proposal, we are testing the hypothesis that the risk of developing prostate cancer and the aggressiveness of the disease are influenced by protein glycosylation. We postulate that glycobiology contributes to the higher susceptibility of African American men. The study population is assembled and an annotated sample repository is ready for use. Methods for the glycomic analysis of fractionated proteins are in place. We are evaluating mRNA datasets comparing prostate cancer in African American and Caucasian men. Our aim is to expand the study in order to evaluate the glycomic changes in prostate cancer health disparity.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2010
Accession Number
ADA546368

Entities

People

  • Radoslav Goldman

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • African Americans
  • Biomedical Research
  • Blood Proteins
  • Caucasians
  • Diseases And Disorders
  • Disparities
  • Gene Expression
  • Genomics
  • Health
  • Immunoglobulins
  • Mass Spectra
  • Materials
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Storage

Readers

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