Role of Cyclin E as an Early Event in Ovarian Carcinogenesis

Abstract

At the genetic level, ovarian cancer is characterized by a large degree of genetic instability. High copy-number amplification at the CCNE1 (cyclin E) gene locus is the single most notable recurrent change, occurring in about 20% of tumors. We have hypothesized that CCNE1 gene amplification is an initiating event in the carcinogenic process of a subset of epithelial ovarian cancers. In the first two years of this award, we have made progress towards testing our hypothesis of cyclin E-induced ovarian cancer initiation in a mouse model. We have also demonstrated the mechanisms underlying the synergistic cytotoxicity of ovarian cancer cells to combination treatment with bortezomib and a natural dietary phytochemical indole-3-carbinole (I3C). The translational relevance could be in the reintroduction of bortezomib to the therapeutic armamentarium against ovarian cancer if the in vitro results replicate in mice and humans.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2011
Accession Number
ADA546740

Entities

People

  • Christine Walsh

Organizations

  • Cedars-Sinai Medical Center

Tags

DTIC Thesaurus Topics

  • Amplification
  • Anti-Bacterial Agents
  • Apoptosis
  • Biotechnology
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chromosomes
  • Epithelial Cells
  • Genetics
  • Gynecologic Cancers
  • Infection
  • Neoplasms
  • Ovarian Cancer
  • Phytochemicals
  • Proteins

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology