Identification of Genes Required for the Survival of Prostate Cancer Cells
Abstract
Prostate cancer, specifically castration-resistant prostate cancer (CRPC), is the second leading cause of cancer-related deaths among men in the United States. The manifestation of prostate tumors capable of evading androgen-dependency results in highly aggressive metastatic prostate cancers that become effectively incurable due to the absence of treatments targeting alternative pathways. To identify novel therapeutic targets distinct from those essential for androgen-dependent prostate tumor survival and proliferation, we have employed a somatic cell genetics approach in the form of a comparative loss-of -function genome-wide shRNA screen. To date, we have identified a family of nuclear hormone receptors as being critically required for prostate cancer growth in culture. We expect our research study, once fully completed, to facilitate the future identification and development of small molecule inhibitors to these potential prostate cancer drug targets.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2011
- Accession Number
- ADA547231
Entities
People
- Stephen Elledge
Organizations
- University of Rochester