Specific PET Imaging Probes for Early Detection of Prostate Cancer Metastases

Abstract

The ultimate goal of this project is to develop specific PET imaging probes for early detection of distal metastases of prostate cancer. Based on one of our studies using a polyarginine (NH2GR11) to deliver a therapeutic moiety to various prostate cancer cell lines, we hypothesize a new group of prostate-specific peptides could be developed as novel PET imaging probes using NH2GR11 as a lead compound for the detection of multi-foci extraprostatic spread of prostate cancer. Three specific aims are arranged to achieve the goals of this proposal: (1) Determine the mechanism of the prostate-specific uptake exhibited by NH2GR11; (2) Design and synthesize novel BFC-peptide conjugates to achieve desired in vivo stability, pharmacokinetics, and enhanced prostate-specific binding affinity; and (3) Establish radiochemical protocols to label peptide conjugates with 64 Cu, and perform in vitro/in vivo evaluations of the potential prostate cancer-specific imaging agents.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
May 01, 2011
Accession Number
ADA547245

Entities

People

  • Xiankai Sun

Organizations

  • University of Texas at Dallas

Tags

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Amino Acids
  • Carbohydrates
  • Cell Line
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Chemical Analysis
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Mass Spectrometry
  • Membrane Lipids
  • Peptides
  • Polymers
  • Polysaccharides
  • Prostate Cancer

Fields of Study

  • Chemistry
  • Physics

Readers

  • Medical Imaging.
  • Oncology (Cancer Research).