Xenon as a Neuroprotectant in Traumatic Brain Injury

Abstract

The purpose of this novel study is to determine if xenon has a neuroprotectant effect in an vivo animal models of TBI. The project scope is an early proof of concept in rat models of xenon neuroprotection. The Specific Aims are to determine the effect of inhaled xenon on brain histopathology, behavior, in short- and long-term fluid percussion (FP) and controlled cortical impact (CCI) rat models of TBI compared to controls. The scope of this project is proof of concept in a rat model. Major findings and progress: IACUC and VA Research Approvals obtained. We developed a recirculation xenon device for this project. Xenon and devices for behavioral studies acquired. Initial experiments using the CCI model do not show significant improvement, rather the contrary, in histopathologic or behavioral outcomes between controls and xenon-treated rats. We are proceeding with the FP model to assess these histopathologic and behavioral outcomes in the short term, and, if promising the long-term.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2009
Accession Number
ADA547294

Entities

People

  • Bruce Kristal
  • Jussi Saukkonen

Organizations

  • Boston VA Research Institute

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Anatomy
  • Animals
  • Biological Sciences
  • Biomedical Research
  • Brain Injuries
  • Department Of Defense
  • Information Operations
  • Instructions
  • Maryland

Readers

  • Aerospace Propulsion Engineering.
  • Neurotrauma and Rehabilitation Medicine.
  • Toxicology/Environmental Toxicology