Endoplasmic Reticulum-Associated Degradation Factor ERLIN2: Oncogenic Roles and Molecular Targeting of Breast Cancer
Abstract
Amplification of the chromosome 8p11-12 region has been found in approximately 15% of human breast cancer and is associated with poor prognosis. Previous genomic analysis has led us to identify an endoplasmic reticulum (ER) lipid raft-associated 2 (ERLIN2) gene as one of candidate oncogenes within the 8p11-12 amplicon in human breast cancer. ERLIN2 is an ER membrane protein that was recently identified as a novel mediator of ER-associated degradation. In the present study, Gain- and loss-of-function approaches demonstrated that ERLIN2 is a novel oncogenic factor that is associated with the ER stress response pathway. We found that ERLIN2 likely facilitates the adaptation of breast epithelial cells to ER stress by supporting cell growth and protecting the cancer cells from ER stress-induced cell death. Thus, ERLIN2 may confer human breast cancer cells a selective growth advantage by promoting a cytoprotective response to various cellular stresses associated with oncogenesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2011
- Accession Number
- ADA547596
Entities
People
- Zeng-quan Yang
Organizations
- Wayne State University