Identification of Biomarkers Associated with the Healing of Chronic Wounds

Abstract

It is the objective of this study to identify the biomarkers associated with the earliest stages of healing in chronic wounds and the biochemical differences in the burn fluid of burns with hypertrophic scarring and those without. The findings of this study are intended to facilitate the development of diagnostic tools, which could be used to evaluate the healing process and develop therapeutic treatments. The analysis of wound fluid from pressure ulcers has revealed differences in the proteins present in the interior versus periphery of the wound. A temporal trend in CXCL9 was detected in healed wounds. A porcine burn model has been used to evaluate healing. PIXIES was used to analyze the cytokines and growth factors present in the burn wounds.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2011
Accession Number
ADA547986

Entities

People

  • Laura E. Edsberg

Organizations

  • Daemen University

Tags

DTIC Thesaurus Topics

  • Biochemistry
  • Biomedical Research
  • Boundaries
  • Burns
  • Chemical Synthesis
  • Chemistry
  • Computational Science
  • Connective Tissue
  • Cytokines
  • Department Of Defense
  • Growth Factors
  • Peptide Growth Factors
  • Proteins
  • Skin Diseases
  • Two Dimensional
  • Wound Healing
  • Wound Infections

Fields of Study

  • Medicine

Readers

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