The Role of Protein Kinase D (PKD) Signaling in Breast Cancer Cell Migration and Invasion

Abstract

The goal of my project as outlined in the original application is to analyze the role of Protein Kinase D (PKD) in breast cancer cell motility, the phenotype critical for metastasis. The work I have conducted includes the demonstration that loss of PKD in a number of highly metastatic breast cancer cell lines results in a migration defect. I have also discovered a novel substrate of PKD that mediates growth factor signals to control the cell motility.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2010
Accession Number
ADA548836

Entities

People

  • Claudine Christoforides

Organizations

  • Beth Israel Deaconess Medical Center

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Membrane Structures
  • Cell Movement
  • Cells
  • Cellular Structures
  • Culture Media
  • Cytoskeleton
  • Enzyme Inhibitors
  • Epithelial Cells
  • Fibroblasts
  • Growth Factors
  • Migration
  • Neoplasms
  • Phenotypes
  • Proteins

Fields of Study

  • Biology

Readers

  • Marine Propulsion Engineering and Naval Architecture
  • Oncology (Cancer Research).