Preclinical Testing of Combination Therapy for Malignant Tumors Arising from Neurofibromas

Abstract

About one half of Malignant Peripheral Nerve Sheath Tumors (MPNSTs) arise in Neurofibromatosis Type 1 patients (NF1). Currently, these tumors present very poor clinical prognosis, and despite efforts to find better chemotherapy, there has been little impact on overall patient survival. The extent of surgical resection is the best prognostic factor for these tumors. Our goal is to identify new combination of receptor tyrosine kinase inhibitors that are effective in cell culture and animal models of MPNSTs. We expect finding effective drug combinations that can be used to treat MPNST patients.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2011
Accession Number
ADA548839

Entities

People

  • Gregory Riggins

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cell Line
  • Cells
  • Culture Techniques
  • Drug Combinations
  • Gene Expression
  • Health Services
  • Inhibitors
  • Instructions
  • Neoplasms
  • Neuromuscular Diseases
  • Peripheral Nervous System
  • Small Molecules
  • Stem Cells
  • Therapy
  • Universities

Fields of Study

  • Medicine

Readers

  • Molecular and Cellular Biology
  • Oncology