Treatment of Shock With Adenosine Receptor Ligands
Abstract
The purpose of the studies conducted in the first reporting period was to begin to investigate the effect of pharmacologicstimulation of A2A or A2B adenosine receptors on trauma/hemorrhagic shock-induced organ injury in rats. The A2A receptoragonist 2-p-(2-carboxyethyl)phenethyl-amino-5'-N-ethyl-carboxamidoadenosine CGS21680 (0.1 and 0.5 mg/kg)exacerbated organ injury when mixed into Ringer s Lactate resuscitation fluid, which was associated with a longlastinghypotensive effect of this agent. In contrast, the A2B receptor agonist BAY 60-6583 (0.5 mg/kg) mixed into Ringer sLactate resuscitation fluid almost completely prevented trauma/hemorrhagic shock-induced lung injury while having noeffect on the blood pressure of rats. We conclude that A2B receptor stimulation is a promising approach in curbinghemorrhage-induced organ failure in the battlefield.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2011
- Accession Number
- ADA548849
Entities
People
- Alexey Trepakov
- Balazs Csoka
- Balázs Koscsó
- György Haskó
Organizations
- University of Medicine and Dentistry of New Jersey