Variations of Human DNA Polymerase Genes as Biomarkers of Prostate Cancer Progression

Abstract

Human DNA polymerases beta, eta, and kappa are enzymes that function in repairing damaged DNA. DNA sequencing analysis of 40 prostate tumors identified somatic mutations of these genes in most patients. Biochemical analysis of the polymerase beta missense variations showed that all of these somatic mutations have functional effects. Thus, common polymerase mutations may contribute to prostate cancer progression.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2011
Accession Number
ADA548987

Entities

People

  • Nick Makridakis

Organizations

  • Tulane University of Louisiana

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Breast Cancer
  • Cancer
  • Carcinoma
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Colon Cancer
  • Crystal Structure
  • Genetics
  • Genomic Instability
  • Liquid Chromatography
  • Neoplasms
  • Oncology
  • Prostate Cancer
  • Spreadsheet Software

Fields of Study

  • Biology

Readers

  • Analytical Mechanics
  • Molecular and genetic basis of cancer.