Columbia SMA Project: A Randomized, Control Trial of the Effects of Exercise on Motor Function and Strength in Patients With Spinal Muscular Atrophy (SMA)
Abstract
This three-year randomized controlled trial is designed to assess the effectiveness of a comprehensive regimen incorporating strengthening and aerobic exercise in 14 ambulatory patients with spinal muscular atrophy (SMA). To date, 13 subjects have been screened and 5 subjects enrolled. Reasons for non-participation were most often cost and burden of travel. Protocol adherence has been outstanding thus far with only one deviation with regards to visit schedule. All testing and intervention procedures have been well tolerated without any serious adverse events. All non-serious adverse events are closely monitored by an independent safety monitor who has approved continuation of the study without modification thus far. The overall goal of this project is to provide novel insights into the effectiveness of aerobic and strengthening exercise to improve function in SMA, and explore the physiology underlying its effects.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2011
- Accession Number
- ADA548997
Entities
People
- Darryl Devivo
Organizations
- Columbia University