Novel Strategy for Lineage Tracing of Cancer Stem Cells by Lentiviral Barcoding

Abstract

In order to characterize the TIC population, we are developing a unique lentiviral barcode strategy to examine the growth kinetics and lineage of tumor cells. These studies are based on the hypothesis that TICs represent a limited subpopulation in breast cancers that give rise to tumor heterogeneity, and that these cells are intrinsically resistant to radiation and chemotherapy. In the first 12 months of the award period, we have successfully completed the first of our two specific aims.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2010
Accession Number
ADA549081

Entities

People

  • Edmund C. Chang

Organizations

  • Baylor College of Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Cells
  • Chemotherapy
  • Department Of Defense
  • Electronic Mail
  • Governments
  • Heterogeneity
  • Information Operations
  • Instructions
  • Kinetics
  • Maryland
  • National Governments
  • Neoplasms
  • Stem Cells

Readers

  • Molecular and genetic basis of cancer.
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology