Hawaii Comprehensive Heart Program

Abstract

Heart disease is the leading cause of death in both the United States and Hawaii. According to the Hawaii State Department of Health, over 1/3 of total deaths in the state are caused by cardiovascular disease, in which approximately 18% (hospital discharges) were associated with heart failure. The potential of stem cells for use in cell therapy to treat diseased or damaged organs is very promising due to the unique properties of these cells, namely the capacity for both long-term self-renewal and differentiation into various mature cell types. There are 2 main objectives for our research, 1) to examine the efficiency of repair and recovery of damaged heart tissue in stem cell based therapies by using enriiched hematopoietic stem cells (HSC) and 2) study the efficiency of trans-differentiation of HSC into cardiomyocytes, following transplantation into damaged (ischemic) heart tissue to promote cardiogenesis.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2011
Accession Number
ADA549083

Entities

People

  • Lawrence Burgess

Organizations

  • University of HawaiĘ»i System

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Bone Marrow
  • Cardiovascular Diseases
  • Cardiovascular System
  • Cells
  • Congestive Heart Failure
  • Department Of State
  • Diseases And Disorders
  • Health Services
  • Heart Diseases
  • Heart Failure
  • Immune System
  • Institutional Review Board
  • Regenerative Medicine
  • Stem Cells
  • United States

Fields of Study

  • Medicine

Readers

  • Energy Conservation and Renewable Energy Engineering.
  • Immunology and Pathology
  • Molecular and Cellular Biology

Technology Areas

  • Biotechnology