Immunotherapy of Prostate Cancer With Genetically Enhanced Tumor-Specific T-Cell Precursors

Abstract

Precursor (Pre) T cells, when adoptively transferred further develop in the thymus into mature T cells, that is capable of lysing tumors. The overall objective of this project is to develop an effective off the shelf adoptive cell therapy with PreT cells targeting prostate cancer. To enhance the anti-tumor activity of PreT cells we transduced these cells with a chimeric antigen receptor (CAR)-Pz1 targeting the prostate cancer associated antigen - prostate specific membrane antigen (PSMA). Here we show that prostate cancer specific PreT cells can be generated by expressing CARs targeting human PSMA. T cells derived from the adoptively transferred PreT cells develop in thymic and extrathymic sites and prolong survival of prostate cancer bearing recipients.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2011
Accession Number
ADA549122

Entities

People

  • Marcel Van Den Brink

Organizations

  • Memorial Sloan Kettering Cancer Center

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Bone Marrow
  • Cancer
  • Cells
  • Culture Techniques
  • Immune System
  • Lymph Nodes
  • Lymphatic System
  • Lymphocytes
  • Neoplasms
  • New York
  • Precursors
  • Prostate
  • Prostate Cancer
  • Survival
  • Targeting
  • Virotherapy

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech