Response of Human Prostate Tissue to Hypofractionated Ionizing Radiation

Abstract

The aim of this proposal is to determine the differences in radiobiological response of human prostate tissue to conventional and hypofractionated radiotherapy. Specifically, this proposal will characterize the predominant DNA damage response pathway from human prostatectomy specimens in response to conventional and hypofractionated ionizing radiation. Data generated in the first year of study has shown that normal prostate tissue and prostate cancer can be cultured ex vivo using a dynamic culture system and used to study the radiobiology of human prostate tissue. Normal prostate tissue responds to ionizing radiation with predicted repair foci (gamma-H2AX and Rad51), and a marker for cellular stress, p53. The DNA damage response in normal glands appears to predominate in the basal cell layer.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2011
Accession Number
ADA549213

Entities

People

  • Thomas Sroka

Organizations

  • University of Arizona

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Cancer
  • Cells
  • Department Of Defense
  • Dose Rate
  • Electronic Mail
  • Ionizing Radiation
  • Medical Personnel
  • Mentoring
  • Neoplasms
  • Oncology
  • Physicians
  • Prostate Cancer
  • Radiation
  • Radiation Oncology
  • Radiotherapy

Fields of Study

  • Medicine
  • Physics

Readers

  • Nuclear and Radiation Engineering.
  • Oncology (Cancer Research).