Cancer-Associated PCNA as a Potential Biomarker for Breast Cancer

Abstract

Two separate isoforms of the marker of cellular proliferation, proliferating cell nuclear antigen (PCNA) have recently been identified. The acidic isoform, as opposed to its basic counterpart has been associated with neoplasia. This cancer associated PCNA (caPCNA) can now be identified by a specific antibody, caPCNAab, demonstrated to distinguish between normal breast tissue and invasive breast cancer by IHC. Additionally, this rabbit polyclonal antibody can also detect circulating caPCNA in the serum of patients with breast cancer (unpublished data). These data suggest that caPCNA may be a potential biomarker of breast cancer and the antibody to caPCNA, caPCNAab, may serve as a detector of breast cancer. The clinical utility of this antibody to cancer specific PCNA is untested. We have proposed to utilize this newly identified antibody, in a recently created ELISA format, to distinguish the cancer associated form of PCNA (caPCNA) from the blood of both normal volunteers and breast cancer patients to evaluate whether there is a statistically significant detectable difference.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2010
Accession Number
ADA549224

Entities

People

  • Ramona Swaby

Organizations

  • Fox Chase Cancer Center

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Antibodies
  • Antigens
  • Biomedical Research
  • Breast Cancer
  • Department Of Defense
  • Detection
  • Detectors
  • Diseases And Disorders
  • Electronic Mail
  • Governments
  • Information Operations
  • National Governments
  • Neoplasms

Fields of Study

  • Biology

Readers

  • Oncology (Cancer Research).