GPR30 Signaling and Regulation in Breast Cancer
Abstract
Estrogen plays a significant role in the progression of breast cancer, leading to increased growth of breast tumors. Until 2005, the classical estrogen receptor, ER , was believed to modulate the entirety of E2-dependent breast cancer growth. In 2005, our lab demonstrated that estrogen binds to and activates the orphan G protein-coupled receptor, GPR30, which has been renamed G Protein Coupled Estrogen Receptor (GPER). Since the discovery of GPR30 as a novel estrogen receptor, it has been established that activation of GPR30 enhances proliferation in many cell types. However, the in vivo effects of GPR30 in breast cancer have not been established. Our preliminary results in a mouse model of breast tumorigenesis demonstrate that inhibition of GPER reduces estrogen-mediated tumor growth.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2011
- Accession Number
- ADA549251
Entities
People
- Nicole A. Marjon