Heterobivalent Imaging Agents for Simultaneous Targeting Prostate-Specific Membrane Antigen (PSMA) and Hepsin

Abstract

We hypothized that the sensitivity and accuracy of prostate cancer diagnosis can be improved by dual-targeting of PSMA and hepsin. In order to provide imaging agents of enhanced affinity/avidity for prostate cancer, Two key components , the PSMA-binding ligand scaffold and the thiadiazole-derived hepsin-binding moieties, were prepared in the Year 1. The ultimate goals throughout the 3-yr project period which synthesize the heterobivalent conjugates of PSMA-ligand with three different types of hepsin ligands and evaluate their in vitro and in vivo biological properties using the optical- or nuclide-labeled conjugates will be accomplished by using the established synthetic methodologies in Year 1.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2011
Accession Number
ADA549277

Entities

People

  • Youngjoo Byun

Organizations

  • Johns Hopkins Hospital

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Amino Acids
  • Analogs
  • Biomedical Research
  • Chemical Synthesis
  • Chemistry
  • Confocal Microscopy
  • Detection
  • Health Services
  • Imaging Techniques
  • Molecules
  • Nanoparticles
  • Neoplasms
  • Prostate Cancer
  • Small Molecules
  • Tomography
  • X-Ray Computed Tomography

Readers

  • Data Mining and Knowledge Discovery.
  • Oncology (Cancer Research).