Early Treatment in Shock

Abstract

This study has rested on two basic hypotheses. The first is that agents given during and (for a short period of time) after resuscitation can favorably influence the response to hemorrhagic shock and injury. The second is that studies of gene response studies, specifically microarray and RT-PCR studies, could be used to assess the response of patients being treated for injuries to such therapeutic agents. To date, both hypotheses have been shown to be true in the animal model. Three therapeutic agents have been identified, of which glutamine appears to be the most suitable for initial use in patients. Clinical studies are ongoing to validate these hypotheses in patients, by using glutamine in patients immediately following resuscitation.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2011
Accession Number
ADA549356

Entities

People

  • Charles Van Way Iii

Tags

DTIC Thesaurus Topics

  • Arteries
  • Biomedical Research
  • Cardiovascular Physiological Phenomena
  • Cells
  • Chemistry
  • Feeding Methods
  • Health Services
  • Hemorrhagic Shock
  • Laboratory Animals
  • Macrophages
  • Medical Personnel
  • Peptide Growth Factors
  • Proteins
  • Therapy

Fields of Study

  • Medicine
  • Psychology

Readers

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