Genetic Modifiers of Ovarian Cancer

Abstract

Individuals with germline mutations in BRCA1 have an elevated but incomplete risk of developing ovarian cancer suggesting the presence of genetic modifiers of ovarian cancer in this population. A genome wide association study (GWAS) for ovarian cancer in BRCA1 mutation carriers was initiated in an effort to identify common genetic variants that modify ovarian cancer risk. The discovery phase of the study has been completed. A replication phase of the 6,000 most significantly associated variants is underway. In a separate study, variants in a 19p13.1 locus have been identified as modifiers of both breast and ovarian cancer in BRCA1 and BRCA2 mutation carriers.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2011
Accession Number
ADA549466

Entities

People

  • Fergus Couch

Organizations

  • Mayo Clinic

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Chromosomes
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Genes
  • Genome
  • Mutations
  • Neoplasms
  • Ovarian Cancer
  • Quality Control
  • Risk
  • Risk Analysis
  • Risk Factors
  • Validation

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Oncology
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology