High Resolution Diffusion Tensor Imaging of Cortical-Subcortical White Matter Tracts in TBI
Abstract
The most significant finding to date is the identification of three potential biomarkers of closed head injury. Although 20 additional subjects are required to complete data collection, our preliminary analyses have shown that thalamic projection fibers in a subgroup of 12 controls and 24 patients with TBI are sensitive to injury and correlate with cognitive function (see Little et al Neurology, 2010). The second year has focused on developing and validating methods to characterize integrity of cerebellar and brain stem fibers. An additional publication has come out of the neuropsychological data and is included. Four additional manuscripts are presently being prepared for submission (expected by 12-2010). Also, the work has been highlighted in 10 invited talks, including a joint DoD, NIH, and VA sponsored conference on mild TBI as part of ATACC. We are well head of schedule and are excited at the significant contributions being made as a result of this award.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2010
- Accession Number
- ADA549548
Entities
People
- Deborah M. Little
Organizations
- University of Illinois at Chicago