The Oncogenic Role of WWP1 E3 Ubiquitin Ligase in Prostate Cancer Development

Abstract

E3 ubiquitin ligase gene WWP1 is a candidate oncogene at 8q21 in human prostate because of gene amplification and over-expression. The purpose of the research is to understand the role and mechanism of WWP1 in prostate cancer development. In a four-year period, we studied functions of WWP1 and its related proteins (KLF5, PMEPA1, RNF11, ErbB4, p63 etc) in prostate and breast cancers. We demonstrated that WWP1 regulates cell proliferation, apoptosis, and migration through ubiquitinating RNF11, KLF5, ErbB4, and p63. The WWP1 interacting protein, PMEPA1, promotes AR-negative prostate cancer cell cycle through suppressing p21 expression. We published 9 research papers, 3 review articles, and 21 abstracts based on this award in the past four years.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2011
Accession Number
ADA549835

Entities

People

  • Ceshi Chen

Organizations

  • Albany Medical College

Tags

DTIC Thesaurus Topics

  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Medical Personnel
  • Peptide Growth Factors
  • Proteins
  • Stem Cells

Readers

  • Breast cancer cell signaling and growth regulation.
  • Prostate Cancer Biology.
  • Technical Research and Report Writing.