Medial Prefrontal Cortex and HPA Axis Roles in Generation of PTSD-Like Symptoms in SPS Model

Abstract

In this report, we will demonstrate that we have a) replicated some pilot findings presented in the initial grant application, b) completed some of the proposed research in specific aims #2 and #3, and c) started research proposed in specific aim #4. We have been unable to replicate our initial SPS effect on social avoidance and freezing induced by trimethlylthiazoline (i.e. predator odor), but are still interested in exploring SPS effects on social behavior (specific aim #2) and regulation of defense behavior (specific aim #3), because we believe these are relevant to the etiology of post traumatic stress disorder. Because we now have to use different animal paradigms to address our specific aims, we have altered our statement of work to reflect this. To date, the research from this grant application has resulted in two peer reviewed journal publications, nine poster presentations, and four manuscripts that are currently being prepared for submission.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2010
Accession Number
ADA550575

Entities

People

  • Dayan Knox
  • Israel Liberzon
  • Sophie George

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Anesthesia
  • Anxiety Disorders
  • Brain
  • Chain Reactions
  • Chemical Reactions
  • Data Analysis
  • Department Of Defense
  • Diseases And Disorders
  • Experimental Design
  • Freezing
  • Human Behavior
  • Medical Personnel
  • Neurosciences
  • Polymerase Chain Reaction
  • Psychiatry
  • Regulations
  • Traumatic Stress Disorder

Readers

  • Neuroscience
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.
  • Technical Research and Report Writing.