The Role of Fatty Acid Metabolism in Estrogen Receptor-Negative Breast Cancer

Abstract

The goal of this proposal was to determine whether there were differences in fatty acid activation between estrogen receptor positive (ER+) and receptor negative (ER-) breast cancer. As a result of support provided by this award, we have been able to expand this investigation to include other hormone receptor biomarkers, and have determined that expression of long-chain fatty acyl-CoA synthetase 4 (ACSL4) is negatively correlated with expression of ER, androgen receptor (AR), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2), and in fact functions as a biomarker of quadruple negative breast cancer (QNBC). In addition, we have demonstrated that expression of ACSL4 is able to mediate estrogen resistance. We are currently assessing the utility of using ACSL4 as a biomarker in the prediction of hormone resistance.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2011
Accession Number
ADA550883

Entities

People

  • Marie Monaco

Organizations

  • New York University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Androgen Receptors
  • Biological Markers
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Estrogens
  • Fatty Acids
  • Growth Factors
  • Hormones
  • Metabolism
  • Neoplasms
  • Patent Applications
  • Proteins
  • Resistance
  • Tumor Cell Line

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