PTEN Loss and Reactive Microenvironments in Prostate Cancer Progression

Abstract

PTEN is lost in a significant percentage of prostate cancers, which has been verified in animal models. However, these models fail to assess the role of PTEN in development given the usage of promoters regulated at differentiation. Results generated by knocking down PTEN in a human model of normal prostatic regeneration show both an arrested differentiation identified with progenitor cell markers and transdifferentiation to various urogenital organs including bladder, urethra and intestine. Each organ type is surrounded by representative differentiated stroma suggesting that gradients of PTEN expression may dictate the development of various urogenital organs. Stromal changes have also been associated with disease progression, which is difficult to model in transgenic animals due to the lack of appropriate promoters.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2011
Accession Number
ADA550912

Entities

People

  • Douglas W. Strand

Organizations

  • Vanderbilt University

Tags

DTIC Thesaurus Topics

  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Disease Attributes
  • Epithelial Cells
  • Glucose Metabolism Disorders
  • Lymphocytes
  • Medical Personnel
  • Metabolic Diseases
  • Prostate Cancer
  • Proteins
  • Stem Cells
  • Urinary Tract

Readers

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  • Prostate Cancer Biology.