Biofunctionalized Zinc Oxide Field Effect Transistors for Selective Sensing of Riboflavin With Current Modulation

Abstract

Zinc oxide field effect transistors (ZnO-FET), covalently functionalized with single stranded DNA aptamers, provide a highly selective platform for label-free small molecule sensing. The nanostructured surface morphology of ZnO provides high sensitivity and room temperature deposition allows for a wide array of substrate types. Herein we demonstrate the selective detection of riboflavin down to the pM level in aqueous solution using the negative electrical current response of the ZnO-FET by covalently attaching a riboflavin binding aptamer to the surface. The response of the biofunctionalized ZnO-FET was tuned by attaching a redox tag (ferrocene) to the 3 terminus of the aptamer, resulting in positive current modulation upon exposure to riboflavin down to pM levels.

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Document Details

Document Type
Technical Report
Publication Date
Jun 27, 2011
Accession Number
ADA550955

Entities

People

  • Burhan Bayraktaroglu
  • Jorge L. Chávez
  • Joshua A Hagen
  • Kevin Leedy
  • Morley O. Stone
  • Nancy Kelley-Loughnane
  • Rajesh R Naik
  • Sang N. Kim

Organizations

  • Air Force Research Laboratory

Tags

Communities of Interest

  • Advanced Electronics
  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Chemical Vapor Deposition
  • Detection
  • Detectors
  • Electronic Mail
  • Field Effect Transistors
  • Materials
  • Materials Processing
  • Military Research
  • Modulation
  • Molecules
  • Pulsed Lasers
  • Semiconductors
  • Silicon Compounds
  • Small Molecules
  • Thin Film Transistors
  • Transistors

Readers

  • Molecular Genetics
  • Nanoscale Plasmonic Nanotechnology
  • Semiconductor Device Technology

Technology Areas

  • Microelectronics
  • Microelectronics - Graphene