Contrast Agents for Micro-Computed Tomography of Microdamage in Bone

Abstract

Novel methods were investigated for detecting damaged bone tissue using contrast-enhanced micro-computed tomography (micro-CT). The presence, spatial location, and accumulation of fatigue microdamage in machined human cortical bone specimens and whole rat femora was non-destructively detected in vitro after labeling by barium sulfate precipitation, and was validated by conventional histology. Micro-CT enabled non-destructive imaging and provided 3-D spatial information, which are not possible using conventional histology. These new methods are immediately useful for in vitro scientific studies investigating the etiology of fatigue and fragility fractures in bone. Functionalized Au NPs were demonstrated to enable targeted delivery and labeled microdamage was detected using synchrotron radiation computed tomography with absorption edge subtraction. Therefore, the results of this study suggest that the ambitious goal of non-invasive (in vivo) imaging of microdamage in bone could be feasible with improvements in commercial scientific and clinical CT instruments

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2011
Accession Number
ADA550968

Entities

People

  • Ryan K. Roeder

Organizations

  • University of Notre Dame

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Bone And Bones
  • Chemical Synthesis
  • Chemistry
  • Detectors
  • Health Services
  • Histological Techniques
  • Materials Science
  • Materials Testing
  • Mechanics
  • Medical Personnel
  • Modulus Of Elasticity
  • Surface Plasmon Resonance
  • Test Methods
  • Three Dimensional
  • Two Dimensional
  • X-Ray Computed Tomography

Readers

  • Medical Imaging.
  • Structural Health Monitoring of Composite Structures.
  • Trauma Surgery or Emergency Medicine.