Accuracy of AccessBio Immunoglobulin M and Total Antibody Rapid Immunochromatographic Assays for the Diagnosis of Acute Scrub Typhus Infection

Abstract

Using archived samples, we assessed the diagnostic capacity of a rapid immunochromatographic test (ICT) for the detection of Orientia tsutsugamushi IgM and total antibodies to aid with the diagnosis of acute scrub typhus infection in febrile patients in Laos. The sensitivity and the specificity of the ICT for the detection of lgM were 96.8% (121/125 samples; 95% confidence interval [CI], 92.1 to 99.1%) and 93.3% (98/105 samples; 95% CI, 86.7 to 97.3%), respectively. For the detection of total antibodies, the sensitivity was 97.6% (122/125 samples; 95% CI, 93.1 to 99.5%), but the specificity was much lower, at 71.4% (75/105 samples; 95% CI, 61.8 to 79.8%).

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2010
Accession Number
ADA551854

Entities

People

  • Kemajittra Jenjaroen
  • Nicholas P J Day
  • Paul N. Newton
  • Rattanaphone Phetsouvanh
  • Stuart D. Blacksell
  • Vanaporn Wuthiekanun
  • Wei-mei Ching

Organizations

  • Naval Medical Research Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Accuracy
  • Antibodies
  • Biomedical Research
  • Data Analysis
  • Dengue
  • Detection
  • Diseases And Disorders
  • Health
  • Health Services
  • Infection
  • Infectious Diseases
  • Malaria
  • Public Health
  • Scrub Typhus
  • Standards
  • Tropical Medicine
  • Wound Infections

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