Reduced Toxicity Breast Cancer Therapy: Changing the Or to And in Dual Targeted Therapeutics

Abstract

The goal of this proposal is to develop a novel delivery system for siRNA therapeutics to enable a more targeted delivery approach than is currently possible. The proposed delivery system relies on two classes of gold nanoparticles each targeted to a separate surface marker and each class containing part of a construct that ultimately will assemble into the therapeutic complex after internalization and release. Only when both classes of gold nanoparticles bind the cell can the therapy be activated. This one year proof-of-principle project will demonstrate the proposed concept using a probe for imaging and knockdown of telomerase in breast cancer cells activatable only in cells which are both HER2+ and EGFR+. As siRNA technologies evolve, such an approach might prove clinically valuable for sub-populations of women whose tumors are both HER2+ and EGFR+.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2010
Accession Number
ADA552005

Entities

People

  • Rebekah Drezek

Organizations

  • Rice University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Antibodies
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Chemistry
  • Flow Rate
  • Gene Therapy
  • Materials
  • Metallic Nanoparticles
  • Nanomaterials
  • Nanoparticles
  • Nanotechnology
  • Neoplasms
  • Particles
  • Standards
  • Therapy

Readers

  • Nanocomposite Materials Science
  • Oncology (Cancer Research).
  • Systems Analysis and Design

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech