Biomarkers of Risk for Post-Traumatic Stress Disorder (PTSD)

Abstract

The objective of this proposal is to study genetic and neuroendocrine biomarkers of risk in a carefully assessed population of military personnel who have recently returned from war zones. The target sample includes 300 men and women who have recently returned from hazardous deployment and are undergoing a comprehensive assessment of symptoms and stressors in a related 12-month longitudinal study. To date, we have enrolled 125 subjects. Samples of saliva have been obtained from all 125 enrolled subjects for analysis of DNA and candidate genes. Cortisol samples have been obtained from 96 of these subjects. Hormone and genetic data will be used to predict the development of PTSD and chronic PTSD. In addition, interactions of these biomarkers with trauma severity and other stressors as well as social supports will be examined.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2010
Accession Number
ADA552047

Entities

People

  • Audrey R. Tyrka

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anticonvulsants
  • Anxiety Disorders
  • Biological Factors
  • Biological Markers
  • Depression
  • Digestive System Processes
  • Electric Stimulation Therapy
  • Genetics
  • Health Services
  • Medical Personnel
  • Military Personnel
  • Mood Disorders
  • Pituitary And Hypothalamic Hormones And Analogues
  • Psychiatry
  • Psychology
  • Students
  • Traumatic Stress Disorder

Fields of Study

  • Psychology

Readers

  • Prostate Cancer Biology.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.

Technology Areas

  • Biotechnology