NF-kB2/p52 Activation and Androgen Receptor Signaling in Prostate Cancer

Abstract

The goal of this project is to characterize the role of NF- B2/p52 in the aberrant activation of AR signaling in castration-resistan prostate cancer. Our preliminary data demonstrate that NF- B2/p52 is expressed at high levels in prostate cancer and tha overexpression of NF- B2/p52 facilitates castration resistant prostate cancer progression by activation of AR signaling and rescue of cancer cells from apoptotic death induced by androgen deprivation. Our hypothesis is that NF- B2/p52 activates the AR and protects prostate cancer cells from apoptotic cell death induced by androgen deprivation therapy, leading to the development of castration resistance prostate cancer. The specific aims are: 1. To determine the role of p52 activation in androgen responsiveness and progression of castration resistant prostate cancer. 2. To determine the effect of expression o p52 on the development and progression of prostate cancer in a transgenic mouse model. 3. To determine the mechanisms o AR activation by p52.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2010
Accession Number
ADA552056

Entities

People

  • Allen C Gao

Organizations

  • University of California

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Diseases And Disorders
  • Gene Expression
  • Health Services
  • Hormones
  • Minority Groups
  • Neoplasms
  • Prostate Cancer
  • Proteins
  • Resistance
  • Tissues

Fields of Study

  • Biology

Readers

  • Molecular Photonics/Laser Physics
  • Oncology (Cancer Research).