IL-6 Receptor Isoforms and Ovarian Cancer Progression

Abstract

During the research period, we have successfully achieved our goals of demonstrating IL6R in the ovarian tumor microenvironment and identifying the differentially-spliced isoform as being prominent. In addition, we have demonstrated an important relationship between IL6R expression and the earliest steps in metastasis of ovarian cancer. Both tumor cells and host myeloid cells contribute to IL6R expression within a tumor, thus providing multiple targets for intervening in ovarian cancer metastasis. Our continuing studies will identify the mechanism by which IL6R influences metastasis and opportunities for preventing or reducing this outcome.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2010
Accession Number
ADA552118

Entities

People

  • Angela F. Drew

Organizations

  • University of Cincinnati

Tags

DTIC Thesaurus Topics

  • Blood
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Epithelial Cells
  • Health Services
  • Medical Personnel
  • Myeloid Cells

Fields of Study

  • Medicine

Readers

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