Volunteer Challenge With Enterotoxigenic Escherichia coli That Express Intestinal Colonization Factor Fimbriae CS17 and CS19

Abstract

Human challenges with enterotoxigenic Escherichia coli (ETEC) have broadened our understanding of this important enteropathogen. We report findings from the first challenge studies using ETEC-expressing colonization factor fimbria CSI7 and CSI9. LSN03-016011/A (LT, CS17) elicited a dosedependent effect, with the upper dose (6 X 10(exp 9) organisms) causing diarrhea in 88% of recipients. WS0115A (LTSTp, CSI9) also showed a dose response, with a 44% diarrhea rate at 9 X 10(exp 9 organisms. Both strains elicited homologous antifimbrial and anti-L T antibody seroconversion. These studies establish the relative pathogenicity of ETEC expressing newer class 5 fimbriae and suggest suitability of the LT!CS17-ETEC challenge model for interventional trials.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2011
Accession Number
ADA552313

Entities

People

  • Barbara Denearing :aisling
  • Chad K Porter
  • Colleen Woods
  • David A. Sack
  • Joyce A. Cantrell
  • Peter Sebeny
  • Robin Mckenzie
  • Shannon L. Grahek
  • Stephanie A. Sincock

Organizations

  • Naval Medical Research Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antibodies
  • Antigens
  • Bacteria
  • Biomedical Research
  • Diseases And Disorders
  • Escherichia
  • Escherichia Coli
  • Governments
  • Health
  • Immune Serums
  • Infectious Diseases
  • Pain
  • Preventive Medicine
  • Signs And Symptoms
  • United States Government
  • Vaccines
  • Volunteers

Fields of Study

  • Biology
  • Medicine

Readers

  • Infectious Disease/Epidemiology
  • Mathematics or Statistics
  • Microbial Pathology