Hemoglobin-based Oxygen Carrier (HBOC-201) and Escalating Doses of Recombinant Factor VIla (rFVIIa) as a Novel Pre-hospital Resuscitation Fluid in a Swine Model of Severe Uncontrolled Hemorrhage
Abstract
Exsanguinating hemorrhage and unavailability of blood are major problems in pre-hospital trauma care. We investigated if combining rFVIIa with HBOC-201 reduces blood loss and improves physiologic parameters compared to HBOC alone. Swine underwent liver injury and were resuscitated with HBOC-201 alone or HBOC+90, 180 or 360 J.lg/kg rFVIIa before hospital arrival at 240 min; animals survived to 72 hours. Blood loss was reduced; MAP, CI, transcutaneous oxygen saturation, and 72-hour survival improved in the 90 and I 80 J.lg/kg rFVIIa groups. Lactate was cleared faster in the HBOC+rFVIIa 90 J.lg/kg group. Verification in a large, well-powered study is indicated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2011
- Accession Number
- ADA552326
Entities
People
- Anke Scultetus
- Aryeh Shander
- Daniel Freilich
- Françoise Arnaud
- Jennifer Rice
- Lewis Kaplan
- Nora Philbin
- Richard Mccarron
Organizations
- Naval Medical Research Center