Dose Response of Sodium Nitrite on Vasoactivity Associated with HBOC-201 in a Swine Model of Controlled Hemorrhage

Abstract

Sodium nitrite (NaN02 ) was evaluated in a 55% EBV hemorrhage swine model to mitigate the increased blood pressure due to HBOC-201. Animals were resuscitated by three lOml/kg infusions of either HBOC-201 or Hextend with and without NaNOr All vital signs, coagulation and blood chemistry were measured for 2hr. HBOC-201-vasoconstriction was attenuated only after the first 10.8 micromol/kg NaN02 infusion. Complete abolition was obtained with the highest 3 NaN02 dose, but side effects were observed. There was no reduction in platelet function due to NaN Or NaN02 ability to reduce HBOC-201 vasoactivity was transient and 10.8 micromol/kg NaN02 seems an acceptable dose for further investigation.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2011
Accession Number
ADA552328

Entities

People

  • Anke H. Scultetus
  • Ashraful Haque
  • Biswajit Saha
  • Bobby Kim
  • Charles Auker
  • Daniel Freilich
  • Françoise Arnaud
  • Paula Moon-massat
  • Richard Mccarron
  • Savita Nigam

Organizations

  • Naval Medical Research Center

Tags

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Blood Chemistry
  • Blood Flow
  • Blood Transfusions
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Hemorrhage
  • Hemorrhagic Shock
  • Oxygenation
  • Sodium Compounds
  • Vital Signs

Fields of Study

  • Biology
  • Medicine

Readers

  • Environmental Engineering
  • Trauma Surgery or Emergency Medicine.