Nitroglycerin Attenuates Vasoconstriction of HBOC-201 during Hemorrhagic Shock Resuscitation

Abstract

Vasoconstriction, an inherent property of Hemoglobin Based Oxygen Carriers (HBOC) potentially due to nitric oxide (NO) scavenging, may increase cardiovascular complications in HBOC resuscitated trauma patients. The purpose of this study was to determine if co-administration of a weak NO donor. intravenous nitroglycerin (NTG), with HBOC-201 during resuscitation from hemorrhagic shock could safely attenuate HBOC-201 vasoconstriction.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2010
Accession Number
ADA552604

Entities

People

  • Charles B. Cairns
  • Charles Sproule
  • Daniel Freilich
  • Gerald Mcgwin Jr.
  • James E. Manning
  • Laurence M. Katz
  • Paula Moon-massat
  • Shane Mccurdy

Organizations

  • Naval Medical Research Center

Tags

DTIC Thesaurus Topics

  • Arteries
  • Attenuation
  • Blood
  • Blood Flow
  • Cardiovascular Diseases
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Diseases And Disorders
  • Health Services
  • Hemoglobin
  • Hemorrhage
  • Hemorrhagic Shock
  • Medical Personnel
  • Methemoglobin
  • Resuscitation
  • Survival
  • United States

Fields of Study

  • Medicine

Readers

  • Astronomy and Astrophysics.
  • Cardiovascular Physiology