Identificaton of Genes Required for the Survival of Prostate Cancer Cells
Abstract
Prostate cancer, specifically androgen-independent prostate cancer, is the second leading cause of cancer-related deaths among men in the United States. Current treatments based on androgen ablation appear to positively select for such tumors, and the resultant highly aggressive, metastatic cancers are effectively incurable due to the absence of treatments targeting alternative pathways. Thus, as originally proposed, we have initiated a novel genome-wide shRNA screen, used successfully in previous loss-of-function screens, to uncover new therapeutic targets distinct from those essential to androgen-dependent prostate tumor proliferation and survival. To this end, we have set out to identify and characterize genes that are selectively required for the proliferation and/or cell survival of prostate cancer cells but not normal prostate epithelial cells. We expect for our research study, once fully completed, to facilitate the future discovery and/or development of small molecule inhibitors to specifically treat prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2010
- Accession Number
- ADA552841
Entities
People
- Stephen Elledge
Organizations
- Brigham and Women's Hospital