Tracked Ultrasound Elastography for Neo-adjuvant Chemotherapy Monitoring
Abstract
We are building a novel monitoring system based on ultrasound elastography which detects the changes in size, shape, and stiffness of tumors in patients receiving neoadjuvant chemotherapy. This system will be used for in-vivo assessment of chemo-sensitivity and early detection of drug resistance. We have developed an ultrasound elastography technique which decreases the dependency of the quality of the images to the expertise of the operator and generates consistent and high-quality strain imaging. It employs information from an external tracker to select frame pairs with minimal lateral and out-of-plane motion, and at the same time, controls the compression rate. We have also devised a customized stereo camera system to accurately reconstruct the surface of the breast for tumor registration and localization. This system projects multiple light patterns on the surface of the breast and resolves for the depth. Experiment on breast phantoms, elastography phantoms, and pig s liver have been carried out to validate the performance of these methods.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2011
- Accession Number
- ADA552868
Entities
People
- Pezhman Foroughi
Organizations
- Johns Hopkins University