M Current-Based Therapies for Nerve Agent Seizures

Abstract

This is a proposal to develop novel, mechanism-based therapies for the treatment of organophosphate (OP) nerve agent-induced seizures. OP nerve agents, such as sarin, soman and VX act by central and peripheral cholinesterase inhibition and enhance cholinergic transmission. In experimental animals, aknown nerve agents produce convulsive seizures and status epilepticus within minutes of exposure. Proposed time table for the Year 1was to a) Obtain regulatory approval for use of animals and obtain drugs. b) Complete experiments 1.1 and & 1.2, 1.3. Start flupirtine part of experiment 3.1, 3.2 and 3.3.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2011
Accession Number
ADA552888

Entities

People

  • Jaideep Kapur
  • Jian L. Sun
  • Marko Todorovic

Organizations

  • University of North Carolina at Charlotte

Tags

DTIC Thesaurus Topics

  • Alkaloids
  • Amplitude
  • Anatomy
  • Anticonvulsants
  • Biological Sciences
  • Biomedical Research
  • Chemical Compounds
  • Cholinergic Nerves
  • Data Analysis
  • Department Of Defense
  • Electrodes
  • Epilepsy
  • Frequency
  • Intervals
  • Nerve Agents
  • Organophosphates
  • Seizures

Fields of Study

  • Medicine

Readers

  • Neurotoxicology
  • Oncology