Delta-Tocotrienol: Radiation Protection and Effects on Signal Transduction Pathways

Abstract

Summary and Conclusions: Survival of gamma-irradiated mouse bone marrow and primary human hematopoietic CD34+ cells was significantly enhanced by Delta-tocotrienol (DT3). DT3 dramatically induced Erk phosphorylation and decreased the DNA-damage marker gamma-H2AX foci formation. DT3 reversed the radiation-inhibited mTOR and S6 protein activation, and induced 4EBP-1 phosphorylation. Knockdown of Erk gene expression by siRNA abrogated DT3-induced mTOR phosphorylation, induced gamma-H2AX foci formation, and inhibited clonogenicity in CD34+ cells. In conclusion, our data suggest DT3 effectively protects mouse bone marrow and human CD34+ cells from radiation damage through the Erk/mTOR survival pathway (Hematological 2010; 95(12) 1996-2004).

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Document Details

Document Type
Technical Report
Publication Date
Jun 15, 2011
Accession Number
ADA553084

Entities

People

  • Mang Xiao
  • Venkataraman Srinivasan

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

DTIC Thesaurus Topics

  • Bone Marrow
  • Bones
  • Carrier Proteins
  • Cell Physiological Processes
  • Cells
  • Countermeasures
  • Gamma Rays
  • Gene Expression
  • Hematopoietic Cells
  • Ionizing Radiation
  • Phosphorylation
  • Proteins
  • Radiation
  • Radiation Protection
  • Survival
  • Vitamin E

Fields of Study

  • Biology
  • Chemistry

Readers

  • Military Engineering.
  • Molecular Biology and Genetics