Sealing Penetrating Eye Injuries Using Photo-Activated Bonding
Abstract
Purpose: To develop a light-activated technology (called PTB) with the potential to decrease vision loss and ocular complications in warfighters sustaining penetrating eye injuries. Scope: In year 2, the scope was to establish the treatment for direct photo-sealing of corneal lacerations, to identify the best treatment for sealing eyelid skin lacerations, and to optimize and build a prototype light delivery system that is safe for the retina. Major findings: Demonstrated that fibrin glue was not competitive with PTB for sealing is amnion over penetrating cornea injuries, determined that two potential adverse effects (inhibition of epithelial cell migration and keratocyte phototoxicity) are not significant problems, demonstrated that PTB can be used to seal lacerations in thin (e.g., eyelid or periorbital) skin without deep sutures and that this repair requires less time than suturing and stimulates less inflammation than sutures, built and tested a prototype retina-safe optical delivery system that effectively seals amnion to cornea and substantially reduces the treatment time compared to the laboratory optical fiber system.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2011
- Accession Number
- ADA553099
Entities
People
- Irene E. Kochevar
Organizations
- Massachusetts General Hospital