Early Detection of Ovarian Cancer by Contrast-Enhanced Ultrasound-Targeted Imaging
Abstract
Because of the lack of an effective early detection method, OVCA in most cases are detected at late stages when the rate of 5-year survival is <10%. Although transvaginal ultrasound (TVUS) is the currently favored method, it cannot detect OVCA at early stage due to its limited resolution. Tumor related malignant nuclear transformation is an earlier event in tumor development which leads to the development of anti-Nuclear Matrix Proteins (NMP) antibodies in circulation. Malignant nuclear transformation is followed by tumor associated neoangiogenesis (TAN). v 3-integrins and death receptors (DR)-6 are the two markers of ovarian TAN expressed by neo-angiogenic microvessels. DR-6 are also secreted in serum. If the detection limit of TVUS can be enhanced, v 3-integrins expressing microvessels can be an in vivo imaging marker of ovarian TAN and may be used together with serum anti-NMP antibodies and DR-6 to detect OVCA at early stage. Our overall goal is to improve the TVUS detectability of ovarian TAN vessels at early stage by v 3-integrins targeted contrast enhanced ultrasound (CE-US) molecular imaging. This goal is being achieved by 3 specific aims. The results so far obtained with the accomplishment of aim 1 and part of aim 2 suggest that CE-US molecular imaging targeting ovarian v 3-integrins can detect ovarian TAN at early stage of OVCA in laying hen model of spontaneous OVCA. Changes in OVCA related CE-US imaging indices are associated with the elevation of serum DR-6 levels. These indices are being used to diagnose hens with OVCA at early stage in aim 2.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2011
- Accession Number
- ADA553100
Entities
People
- Animesh Barua
Organizations
- Rush University