Regulation of Cell Migration in Breast Cancer
Abstract
Cell migration is an essential cellular process and deregulation of this process may result in serious consequences such as tumor metastasis. Numerous studies have demonstrated that the IPP complex is linked to cell adhesion and cell migration. Our lab has found that Rsu-1 binds to the IPP complex through PINCH1 5 and the absence of either Rsu-1 or PINCH! proteins results in a change in epithelial cell migration. In addition, the levels, the forms and the subcellular localization of Rsu-1 and 1PP proteins are altered in breast cancer cells compared to non-tumorigenic mammary epithelial cells. particular, the Rsu-1 variants contribute to breast cancer cell migration. Therefore, it is my hypothesis that Rsu-1 splice variant(s) contribute to cell migration by functioning as a regulator of essential migration processes. In addition, the presence ofRsu-1 splice variant(s) may enhance migration in tumorigenic mammary epithelial cell lines. Since focal adhesion formation and stabilit(, G-protein signaling and actin polymerization are fundamental in the process of cell migration, the information that we gather relevant to these processes will further om understanding of the role of the IPP complex and Rsu-1 in the regulation of cell migration. This research is proposed to elucidate the mechanistic role of Rsu-1 in breast cancer cell migration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2011
- Accession Number
- ADA553111
Entities
People
- Reyda Gonzalez-nieves
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine