NF-KappaB2/p52 Activation and Androgen Receptor Signaling in Prostate Cancer

Abstract

The goal of this project is to characterize the role of NF-kappaB2/p52 in the aberrant activation of AR signaling in castrationresistant prostate cancer. Our preliminary data demonstrate that NF-kappaB2/p52 is expressed at high levels in prostate canceand that overexpression of NF- B2/p52 facilitates castration resistant prostate cancer progression by activation of AR signalingand rescue of cancer cells from apoptotic death induced by androgen deprivation. Our hypothesis is that NF-kappaB2/p52activates the AR and protects prostate cancer cells from apoptotic cell death induced by androgen deprivation therapy, leadingto the development of castration resistance prostate cancer. The specific aims are: 1. To determine the role of p52 activation inandrogen responsiveness and progression of castration resistant prostate cancer. 2. To determine the effect of expression op52 on the development and progression of prostate cancer in a transgenic mouse model. 3. To determine the mechanisms oAR activation by p52.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2011
Accession Number
ADA553268

Entities

People

  • Allen Gao

Organizations

  • University of California

Tags

DTIC Thesaurus Topics

  • Ablation
  • Abstracts
  • Androgen Receptors
  • Androgens
  • Biomedical Research
  • Cancer
  • Castration
  • Cell Physiological Processes
  • Cells
  • Coding
  • Demographic Cohorts
  • Department Of Defense
  • Deprivation
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Resistance

Fields of Study

  • Biology

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