Obstructing Androgen Receptor Activation in Prostate Cancer Cells Through Post-translational Modification by NEDD8

Abstract

The overall goal of this study is to investigate the effect of post-translational NEDD8 modification on androgen receptor. In year 3, we proposed to establish Jab1 shRNA expressing lines of prostate cancer cells and to characterize the effects of Jab1 silencing on prostate cancer cell growth and proliferation. Several stable cell lines have been established, and experiments are being conducted to characterize these cell lines. These works are currently being continued into the final no-cost extension year.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2011
Accession Number
ADA553448

Entities

People

  • J. D. Chen

Organizations

  • Robert Wood Johnson Medical School

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Biomedical Research
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins

Readers

  • Applied Combinatorial Optimization and Logic Circuit Design.
  • Oncology (Cancer Research).
  • Prostate Cancer Biology.